NFKB1 and common variable immunodeficiency: Genomic variants with a high Combined Annotation Dependent Depletion score were found within both the PID and control cohorts, suggesting that this commonly used metric of variant deleteriousness cannot reliably distinguish disease-causing from benign variants in NFKB1. All 16 predicted likely pathogenic variants were private to the PID cohort, and further investigation revealed that all 16 subjects were within the diagnostic criteria of CVID (Table I).