By delineating new functions of HDAC4 in neurogenic muscle atrophy, our work represents a step-forward toward the development of efficient pharmaceutical approaches for neurogenic muscle atrophy, possibly by combining HDAC inhibitors with antioxidant drugs or with other treatments aiming to boost the catabolic pathways in skeletal muscle, otherwise compromised using HDAC inhibitors. This evidence concerns the gene HDAC9 and Skeletal muscle atrophy.