Our present findings in X‐ALD identified the differential methylation in the DMRs of the immune‐associated genes IFITM1 and CD59. Interestingly, the IFITM1 gene, which is overexpressed in X‐ALD, belongs to the interferon signature pathway and plays a role in the host defense against intracellular bacterial/viral infection. The gene discussed is CD59; the disease is adrenoleukodystrophy.