Thus, in X‐ALD samples, we identified the significant downregulation of (i) NINJ2; (ii) the myelin regulatory factor MYRF, which is required for central nervous system myelination and oligodendrocyte differentiation; (iii) the oligodendrocytic myelin paranodal and inner loop protein OPALIN; (iv) and the oligodendrocyte transcription factor 1 OLIG1, which also appears to play a critical role in late‐stage oligodendrocyte maturation and myelin formation 56. Here, MYRF is linked to adrenoleukodystrophy.