Among transcripts that were repressed in X‐ALD in both adults and children with respect to controls and hypermethylated gene‐associated DMRs, we detected downregulation of the myelin genes CNP, MBP, PLP1, MOG, MOBP, MAG and the ninjurin 2 protein (NINJ2), a cell surface adhesion protein that is upregulated in Schwann cells surrounding the distal segment of an injured nerve, promotes neurite outgrowth and is present in the enriched oligodendrocyte differentiation gene set (Supporting Information Table S5). This evidence concerns the gene PLP1 and adrenoleukodystrophy.