DKK3 has been shown to be a useful biomarker when used in a protein biomarker panel with IGFBP2 and PKM2, and shown to have the equivalent sensitivity to the fecal occult blood test (FOBT) for the detection of early stage CRC.18 Given that the majority of our patients were diagnosed with low‐grade adenocarcinoma following endoscopy (8× Stage I–IIA and 1× Stage IIIB), we examined these three biomarkers by PRM (all three were detected during our comparative and quantitative analyses, Table 4, Supporting Information). The gene discussed is DKK3; the disease is colorectal carcinoma.