ZIKV infection has previously been reported in the spinal cords of AG129 mice (Julander et al. 2017; Zmurko et al. 2016), and ZIKV-induced histopathology or myelitis has been observed in IFNAR−/− (Lazear et al. 2016) and Swiss Webster mice infected as newborns (Fernandes et al. 2017). Here, IFNAR1 is linked to Zika virus infectious disease.