Given that mTOR signaling plays an important role in protein synthesis, including translational control of Kv1.1, and that changes in Kv1 channel expression are associated with epilepsy, we investigated whether constitutive mTOR hyperactivation is associated with alterations in Kv1 channel expression in a previously characterized neuronal subset-specific Pten knockout mouse model of CD with epilepsy20. Here, PTEN is linked to Cowden disease.