The neuromorphological hallmarks of AD are cerebral amyloidogenesis, i.e., the accumulation of amyloid-β (Aβ) in the form of extracellular, insoluble aggregates (so-called amyloid plaques) in specific brain regions, intraneuronal neurofibrillary tangles (the major component of which is hyperphosphorylated tau protein), and neuronal degeneration2. This evidence concerns the gene MAPT and Alzheimer disease.