The apoptosis in NPs cells of the circ-GRB10 overexpression group was significantly suppressed compared with the mock circRNA vector group (P < 0.001); nevertheless, circ-GRB10 knockdown markedly increased the NP cell apoptosis rate (P < 0.001); circ-GRB10 could significantly stimulate NP cells survival under nutrient deprivation conditions (P < 0.01) (Fig. 8h). This evidence concerns the gene GRB10 and nail-patella syndrome.