Moreover, TRAIL treatment dramatically increased the apoptosis rate of tumor cell; the overexpression of miR-24 and miR-221 could reduce tumor cell apoptosis rate upon TRAIL treatment, in other words, attenuate the promotive effect of TRAIL on tumor cell apoptosis; on the contrary, the inhibition of miR-24 and miR-221 could increase tumor cell apoptosis rate upon TRAIL treatment, that is, amplify the promotive effect of TRAIL on tumor cell apoptosis (Fig.2e). The gene discussed is TNFSF10; the disease is neoplasm.