Combined with the results from luciferase assays, CASC2 competitively binds to miR-24/miR-221 to reduce binding of miR-24/miR-221 to downstream caspase 3/8, thereby affecting TRAIL-resistant tumor cell viability, caspase 3/8 protein levels, and finally TRAIL-induced tumor cell apoptosis. This evidence concerns the gene TNFSF10 and neoplasm.