Through targeting tumor suppressors phosphatase and tensin homolog (PTEN) and metalloproteinase inhibitor 3 (TIMP3), these two miRNAs are able to induce TRAIL resistance; moreover, MET is also reportedly involved in the activation of miR-221 and miR-222 in non-small cell lung cancer and hepatocellular carcinoma44. This evidence concerns the gene MET and non-small cell lung carcinoma.