These results indicate that TFPI is inversely related to the ability of invasion and metastasis of BrCa and may also confirm that luminal-A BrCa presents the possibility of a more favourable outcome for patients in view of the non-haemostatic; tumour-suppressive activities of TFPI and anti-angiogenic and antimigratory properties of TFPI. This evidence concerns the gene TFPI and neoplasm.