Furthermore, H. pylori infection can cause methylations on CpG islands of E-cadherin [54] and tumor-suppressor genes, including those encoding the trefoil factor 2 (TFF2) and a forkhead box transcriptional regulator (FOXD3), resulting in the significantly increased risk of adenocarcinoma in the stomach [55]. The gene discussed is TFF2; the disease is adenocarcinoma.