Of interest, it should be noted that even in the absence of CD8 T cells (CD8 depletion), ALVAC-specific CD4 T cells were still significantly less susceptible to HIV infection than Ad5 vector-specific CD4 T cells (5.63 ± 1.84 vs 28.56 ± 5.16; p = 0.0002) (Fig 8B), suggesting that CD8 T cells contributed only partly to the low HIV susceptibility of ALVAC-specific CD4 T cells as compared to Ad5 vector-specific CD4 T cells. This evidence concerns the gene CD4 and HIV infectious disease.