MTHFR and familial pancreatic carcinoma: Li et al. reported a 2-fold increased risk for pancreatic cancer for individuals with the MTHFR 677 TT versus the CC/CT polymorphisms while Wang et al. reported increased odds ratios of 2.6 and 5.1 for the CT and TT genotypes, respectively, versus the wild-type CC polymorphism [16,18].