MTHFR and familial pancreatic carcinoma: While we did not find statistically significant associations of pancreatic cancer with either of the MTHFR SNPs, the percentage of pancreatic cancer patients with the VV genotype in the A222V SNP, with the lowest RBC folate levels, is almost double that of unrelated control subjects (16% vs 9%, respectively; Table 3), and the percentage of pancreatic cancer patients with the EE genotype of the E429A SNP, with lower RBC folate levels, is also greater than that of unrelated control subjects (54% vs 44%, respectively; Table 3).