However, the Sirt6-/-Trp53+/- mice developed other types of tumors, such as kidney tumor (19%), prostate tumor (17%), bladder tumor (16%), and pancreatic tumor (8%) (Figure 3—figure supplement 1C–F respectively), while only 3% of them exhibited incidence of sarcoma. This evidence concerns the gene SIRT6 and urinary bladder neoplasm.