TP53 and neoplasm: On the other hand, given both SIRT6 and p53 are potent tumor suppressors (Donehower and Lozano, 2009; Sebastián et al., 2012) and their regulatory roles in aging, this study opens a new window for future study in the control of choice between aging and cancer development by the balance and cross-talk of p53 and SIRT6.