PIGL mutations have been reported mainly in individuals with CHIMEsyndrome (eight individuals, including a pair of brothers and the present case), oneindividual reported by Fujiwara (Fujiwara etal., 2015), clinically diagnosed as Mabry syndrome, and oneindividual recently reported by Pagnamenta (Pagnamentaet al., 2017) whose clinical and laboratorial findingswere also reminiscent of Mabry syndrome. This evidence concerns the gene PIGL and hyperphosphatasia-intellectual disability syndrome.