PIGL and CHIME syndrome: CHIME syndrome is an extremely rare autosomal recessive multisystemic disordercaused by mutations in PIGL. PIGL is an endoplasmic reticulumlocalized enzyme that catalyzes the second step of glycosylphosphatidylinositol(GPI) biosynthesis, which plays a role in the anchorage of cell-surface proteinsincluding receptors, enzymes, and adhesion molecules.