Without a magnetic field, the cell viability of HeLa cells treated with M-MSN(DOX)/PEI-FA/VEGF shRNA nanocomplexes was lower than the that of cells incubated with M-MSN(DOX)/PEI-FA and M-MSN/PEI-FA/VEGF shRNA nanocomplexes alone, which made clear that the penetration and uptake of DOX in tumor cells were increased by VEGF shRNA and a synergistic or superimposed treatment effect could be obtained. Here, VEGFA is linked to neoplasm.