SCN5A and sick sinus syndrome: HEK-293 cells are often considered more reliable because of their mammalian origin, but in a comparative study on nine different sick sinus syndrome-related mutations in SCN5A, not including 1795insD, Gui et al. [46] found that most of the electrophysiological parameters obtained with oocytes were not different from those obtained with HEK-293 cells (all recordings made at a room temperature of 20–22 °C).