SCN5A and Sinus bradycardia: Furthermore, they can help explain the sinus bradycardia that is observed in other mutations in SCN5A that exhibit some of the effects of the 1795insD mutation, like the E161K mutation, which is associated with an almost threefold reduction in peak sodium current and a +11.9 mV shift in steady-state activation, but does not show a persistent current or changes in inactivation properties [43].