Finally, wild-type immunocompetent mice, ifnar−/− mice and Interferon Alpha Receptor (IFNAR)-depleted rag1−/− mice, have helped to characterize the phenotype of responding T cells after ZIKV infection and to demonstrate the protective effect of CD8+ T cells against ZIKV infection in various organs, including the brain and testes [98,99,100]. Here, RAG1 is linked to Zika virus infectious disease.