CD8A and dengue disease: In addition, protection or susceptibility to severe dengue disease has been associated with the expression of certain Human Leukocyte Antigen (HLA) molecules [68,69,70,71,72,73] and a beneficial function of CD8+ T cells against DENV infection was demonstrated after depletion of the CD8 T-cell compartment in interferon-α receptor knock-out mice (ifnar−/−) [74].