Type I interferon receptor-deficient mice expressing human HLA class I molecules (HLA-B*0702 or HLA-A*0101), which are susceptible to DENV and ZIKV infection, enabled identification of ZIKV peptides that are targeted by CD8+ T cells, and to show that dengue or Zika virus infections can induce the development of cross-reactive CD8+ T cells that are protective against ZIKV infection [90]. This evidence concerns the gene HLA-A and Zika virus infectious disease.