As expected, bovine α-LAH significantly suppressed phosphorylation of IKKα/β, JNK, ERK and p38 (Figure 6 and Figure 7), which provide compelling evidence that bovine α-LAH effectively interferes with the IKK and MAPK signaling pathways in adipose tissues, thereby contributing to its protective effects against insulin resistance and inflammation. The gene discussed is MAPK8; the disease is Insulin resistance.