The current study demonstrated that the administration of En-OPS significantly decreased serum AST, ALT, and ALP levels; inhibited MDA and LPO formation; enhanced antioxidant enzyme activities; and scavenged hydroxyl, superoxide, and DPPH radicals, indicating that En-OPS possessed potential antioxidant abilities and protective effects on acute alcohol-induced ALD. The gene discussed is GPT; the disease is alcohol dependence.