In addition, HCGβ can also modulate the expression of epithelial‐to‐mesenchymal transition (EMT)‐related genes, including suppressing E‐cadherin and increasing phospho‐SMAD2, SNAIL and TWIST in colorectal cancer cells, the effects of which are similar to that of TGFβ11. The gene discussed is TWIST1; the disease is colorectal cancer.