This involves enhanced expression of stress‐regulated protein p8 (Nupr1), transcriptional regulator, taking part in a control of tumor development, as well as its downstream targets, activating transcription factor 4 (ATF4), C/EBP homologous protein (CHOP), and Tribbles homolog 3 (TRIB3) (Fig. 1) 36, 37. This evidence concerns the gene TRIB3 and neoplasm.