EGFR and cancer: Studies in vitro have shown that submicromolar concentrations of CB receptor agonists cause increase in the proliferation of certain cancer cell lines and that this effect was dependent on an activity of ADAM17 metalloprotease, an activation of epidermal growth factor receptor (EGFR), and subsequent stimulation of extracellular signal‐regulated kinases (ERK) and Akt pathways 33.