Clinical evidence also suggests that patients with hypermethylation on the promoter region of tumor suppressive genes, such as Ras association domain family member 1 (RASSF1A) 35, BRMS133, and breast cancer type 1 susceptibility gene (BRCA1) 36, 37, 38, are associated with poor prognosis. The gene discussed is BRCA1; the disease is neoplasm.