And CYR61 was also able to promote breast cancer cell proliferation, cell survival, and Taxol resistance through an alphavbeta3‐activated ERK1/ERK2 MAPK signaling 26 and to confer resistance to mitoxantrone via spleen tyrosine kinase activation in human acute myeloid leukemia 27. Here, CCN1 is linked to acute myeloid leukemia.