And CYR61 was also able to promote breast cancer cell proliferation, cell survival, and Taxol resistance through an alphavbeta3‐activated ERK1/ERK2 MAPK signaling 26 and to confer resistance to mitoxantrone via spleen tyrosine kinase activation in human acute myeloid leukemia 27. This evidence concerns the gene MAPK1 and acute myeloid leukemia.