Surfactant protein D binds directly to high mannose-type N-glycans in EGFR and the interaction blocks the binding of epidermal growth factor (EGF) to EGFR, suppressing EGF signaling and inhibiting the proliferation and migration of two human lung adenocarcinoma epithelial cell lines, indicating that lung cancer cells are regulated by SP-D via autocrine mechanisms (158, 178). This evidence concerns the gene SFTPD and lung cancer.