This “double hit” not only appears to contribute to a greater severity of retinal devolution, but it also demonstrates the coexistence of SNHL, ARRP, and a mutation in PDE. The aforementioned genetic syndromes, along with a growing number of disorders that are associated with PDE, all make the case that a successful PDE-treatment modality might not only be applied to multiple disorders, but is certain to have vast interdisciplinary effects. Here, ALDH7A1 is linked to sensorineural hearing loss disorder.