Consistent with this, generation of these populations was found to be largely STAT3-independent, as shown by normal frequencies of CXCR3+CCR6− and CXCR3−CCR6− and IFNγ-producing and IL-4, IL-5, IL-13-producing cells, respectively, in AD-HIES patients (28, 37, 38). The gene discussed is STAT3; the disease is Alzheimer disease.