Intracellular production of RANKL was higher in CD4+CD28− T-cells compared to that in CD4+CD28+ T-cells [MFI: 901.5 (630–1069) vs. 660.5 (443–796), p = 0.028, Figure 2C] in patients with RA. The gene discussed is TNFSF11; the disease is rheumatoid arthritis.