In contrast in AD brains, HMW-tau was phosphorylated at all phosphorylation sites studied, which include Ser181, Ser199, Ser202/Thr205, Thr205, Thr212, Ser214, Thr217, Ser262/356, Ser396, Ser404 and Ser422 (Figures 2A,B). Here, MAPT is linked to Alzheimer disease.