NPR2 and acromesomelic dysplasia 1, Maroteaux type: Carrier parents of individuals with AMDM and heterozygous mutations in NPR2 are associated with a slight reduction in height in comparison to the population average (Olney et al., 2006; Vasques et al., 2013; Hisado-Oliva et al., 2015) which was also found for mice heterozygous for Npr2 (Tamura et al., 2004).