As expected, Cortactin expression was reduced in Hakai-MDCK xenograft tumours compared to MDCK-injected cells, supporting in vivo the previous in vitro reported action of Hakai in the ubiquitination and degradation of Cortactin (Fig. 4B, right panel and Supplementary Fig. 5, right panel)12. Here, CBLL1 is linked to neoplasm.