CBLL1 and cancer: Taken together and given that Hakai expression is enhanced in human tumour progression in colon adenocarcinoma compared to normal tissues (Fig. 1), our results reinforce that proteasome inhibitors may not be an effective treatment for epithelial tumours that follow EMT and we propose the E3 ubiquitin-ligase Hakai as a better therapeutic target against cancer in specific molecular subtypes of colorectal cancer already defined47,48.