At the ankle level, higher sclerostin concentration was observed at the protein level in the AIA group compared to CTRL group from day 6 to 10 (Fig. 5D, p < 0.05), while SFRP1 protein expression was only enhanced after arthritis onset (Fig. 5E, p < 0.01). The gene discussed is SFRP1; the disease is arthritic joint disease.