Due to its emerging role in neurodegeneration and a strong genetic link to Parkinson’s disease (PD)3–9, the gene coding for iPLA2β was designated as PARK14. Originally isolated from myocardial tissue as an activity stimulated during ischemia10,11, the enzyme displays several specific features including calcium-independent activity, a preference for plasmalogen phospholipids with arachidonate at the sn-2 position, an interaction with ATP12 and inhibition by calmodulin (CaM) in the presence of Ca2+13. The gene discussed is ATPAF2; the disease is Parkinson disease.