As shown in Fig. 1a and Fig. 1 suppl., ITF2357 strongly reduced sarcoma cell viability regardless of p53 status, with IC50 values ranging from 3 μM in the p53 null line SaOS2, to 0.57–0.97 μM in p53-mutant lines (SW872, SKLMS) and 0.63–0.88 μM in wild-type (wt) p53 lines (U2OS, SW982, HT1080, A204). This evidence concerns the gene TP53 and sarcoma.