Firstly, we assessed the effect of ITF2357 on cell viability of a panel of established human sarcoma cell lines showing different p53 status, including osteosarcoma (SaOS2, U2OS), liposarcoma (SW872), synovial sarcoma (SW982), fibrosarcoma (HT1080), rhabdomyosarcoma (A204), and leiomyosarcoma (SKLMS), that represent the major histological entities of sarcoma family. Here, TP53 is linked to osteosarcoma.