For example, TGF-β regulated miR-34a promotes venous metastases of HBV-positive HCC by CCL22 signaling-recruited immunosuppressive cells and promotes the escape of HCC cells from immune surveillance.13 Previous reports also showed that potential novel miRNAs were expressed neither in normal hepatic stem cells nor in differentiated HCC cells but rather in hepatic cancer stem cells (CSCs).14 Here, CCL22 is linked to hepatocellular carcinoma.