TYR and neuroblastoma: Researchers have shown that LEF1 can function as a transcription factor to transactivate the expression of the tyrosinase (TYR) gene by physically interacting with its promoter.31 LEF1 facilitated the heparanase (HPSE) transcription via directly binding to its promoter in neuroblastoma (NB) cell lines.32 Therefore, we hypothesize that LEF1 could bind to the miR-HCC1 promoter region to affect the expression level of miR-HCC1.