VIM and cancer: Numerous studies have shown that miRNAs can regulate cancer invasion and metastasis by epithelial to mesenchymal transition (EMT)-related mechanisms.16 The EMT process that converts epithelial cells into mesenchymal cells is activated during cancer invasion and metastasis, and cells lose their epithelial features and acquire mesenchymal properties.26 A characteristic of EMT is the loss of E-cadherin and cytokeratin-1 and the acquisition of vimentin and ICAM-1.