MicroRNAs (miRNAs) are a class of short endogenous non-coding RNAs approximately 22 nucleotides in length that suppress gene expression by targeting mRNA 3′untranslated regions (3′UTR) or enhance gene expression by binding mRNA 3′UTR in a G-rich RNA sequence binding factor 1 (GRSF1)-dependent manner.4–7 miRNAs participate in a variety of biological progresses, including proliferation, differentiation, and apoptosis.8 Over the last decade, researchers have established an association between aberrant miRNA expression and tumorigenesis of HCC. The gene discussed is GRSF1; the disease is hepatocellular carcinoma.