Increased expression of AQP4 mRNA was significantly correlated with poor OS for all ovarian cancer, HR = 1.54 (1.2–1.97), P=0.00062 (Figure 6A) and serous ovarian cancer, HR = 1.55 (1.17–2.05), P=0.0022 (Figure 6B). The gene discussed is AQP4; the disease is ovarian serous adenocarcinoma.