In our current analysis, we found that high level of AQP1, AQP4, and AQP8 mRNA expression in TP53 mutation and AQP1 mRNA expression in TP53 wild-type ovarian cancer patients were correlated with poor survival rate, indicating that mutation of TP53 gene might regulate AQP1, AQP4, and AQP8 expression and participation in the development of ovarian caners. Here, AQP4 is linked to ovarian cancer.