For example, the lifetime QALYs gain was 0.42 for intravenous tPA treatment for acute ischaemic stroke within 4.5 hours,33 and 0.17 for clopidogrel for secondary prevention of stroke compared with aspirin.34 This may be due to the large magnitude of the effect of the mechanical thrombectomy (OR 2.046). This evidence concerns the gene PLAT and Stroke.