The most pronounced upregulated genes in the choroid plexus of transgenic mice were of Il6, Nos2, Lcn2, Mmp8, and Mmp13. Interestingly, in agreement with the data obtained from human AD patients, Tnf and Tnfrsf1a were not differentially expressed in the choroid plexus of APP/PS1tg/wt mice. The gene discussed is MMP8; the disease is Alzheimer disease.