SLC7A11 and myeloid sarcoma: In 2011, Pampliega and colleagues reported that the light chain of the heterodimeric xc- transmembrane protein (known as xCT) responsible for its transporter activity is upregulated in the spinal cord of mice and rats with experimental autoimmune encephalomyelitis (EAE), the most widely characterized rodent model of MS, as well as human MS postmortem tissue [6].