TNF and Alzheimer disease: The neuroinflammation in AD brain involves an activation of microglia and astrocytes around the Aβ plaques [7, 8], which triggers several cascade pathways, including secretion of pro-inflammatory cytokines, such as interleukins (ILs), tumor necrosis factor-α (TNF-α), prostaglandin, nitric oxide (NO), which are all highly associated with neurodegeneration in AD [9–11].