As T cells, CD103+ CD11b+ DCs and ILC3s are all important in initiating and propagating ILC3/TH17 responses in the intestine [27–30] and these population are perturbed in Hic1Vav mice, we next sought to determine the effect of HIC1 deficiency in these specific cell populations during infection C. rodentium. We crossed Hic1fl/fl mice with mice expressing Cre under the control of either the Cd4 promoter or Itgax (CD11c) promoter to generate T cell-specific (Hic1CD4 mice) and dendritic cell-specific (Hic1CD11c mice) HIC1-deficient mice. This evidence concerns the gene ITGAX and infection.