In order to determine the contribution of CD30+CD4+ T cells to the total RNA and DNA burden of HIV-1 infection in peripheral CD4+ T cell compartments, we compared the total HIV-1 RNA and DNA recovered from each T cell subset, taking into account the number of cells obtained, from ART suppressed (n = 17), viremic donors (n = 9) and HIV controllers (n = 3). The gene discussed is TNFRSF8; the disease is HIV-1 infection.