Nonetheless, this finding was unexpected as we have observed detectable HIV-1 DNA and RNA in PBMC from all other HIV-1-infected individuals in a cohort of 15 patients who completed multiple cycles of systemic chemotherapy (not including Brentuximab) for a variety of solid organ and hematological malignancies, as we have previously reported [27] (CD4+ T cell-associated HIV-1 DNA increased from a mean of 2,204 copies/106 cells to 43,961 copies/106 cells following completion of cancer chemotherapy in 10 individuals with pre- and post-chemotherapy time-points available). Here, CD4 is linked to hematologic disorder.