CDH1 and ulcerative colitis: There was also no correlation identified with ECAD, a tight junction element, which has been shown to decrease with ulcerative colitis and Crohn's disaese53, 54 and IBD in dogs.28 Last, there was no correlation with CLD2, another tight junctional element that increases with intestinal inflammation in people,55, 56, 57 and in dogs with CE.29