ADGRE5 and nonpapillary renal cell carcinoma: According to the here analyzed databases aGPCRs which are related to vascularization (Adgre1, Adgre5, Adgra2) (Wang et al., 2005; Cullen et al., 2011; Wandel et al., 2012) or inflammatory processes (Adgre1, Adgre2, Adgre5) (Gray et al., 1996; Taylor et al., 2005; Hamann et al., 2007; Kuan-Yu et al., 2017) are >2.5-fold upregulated in ccRCC (Table 2).