ADGRG2 is highly expressed in several human cancer cell lines including 8 human RCC cell lines: CAKI-1, 786-0, A498, ACHN, SN12-C, (all ccRCC), TK-10, RXF 393, and UO-31 (Richter et al., 2013). Here, ADGRG2 is linked to nonpapillary renal cell carcinoma.