Besides a role in kidney, ADGRL4 upregulation is according to the Neprhoseq database associated with IgA nephropathy (33 human samples, 2.757 fold change, p = 5.18E-12) as well as lupus nephritis (46 human samples, 5.493 fold change, p = 2.46E-7). The gene discussed is ADGRL4; the disease is lupus nephritis.