Consistent with the fact that the kidney develops macrophage-associated local inflammation in response to metabolic disorders, such as insulin resistance and diabetes (Navarro-González and Mora-Fernandez, 2008; Declèves and Sharma, 2015), Adgrg3 is according to the Nephroseq database upregulated in the mouse model of diabetic nephropathy (12 samples, 2.938 fold change, p = 2.55E-6). The gene discussed is ADGRG3; the disease is diabetic kidney disease.