Increased expression levels were found for ADGRL2, ADGRL4, ADGRE1, ADGRE5, ADGRG2, and ADGRG6 in lupus nephritis and diabetic nephropathy, whereby ADGRL2, ADGRL4 and ADGRE5 were also upregulated in IgA nephropathy (Table 2). The gene discussed is ADGRE5; the disease is diabetic kidney disease.