A role of these genes in vascular and/or inflammation-mediated kidney diseases is further substantiated by the associations with diabetes nephritis (ADGRE1, ADGRE5), lupus nephritis (ADGRE1, ADGRE2, ADGRE5), renal vasculitis (ADGRE2, ADGRE5), IgA nephropathy (ADGRE5) and renal hypertension (ADGRE5). Here, ADGRE1 is linked to lupus nephritis.