ADGRG1 knockdown resulted in melanoma growth inhibition and regression (Ke et al., 2007), while knockdown of the other 2 aGPCRs reduced lung (ADGRF5) (Tang et al., 2013) and/or bone metastasis (ADGRE5, ADGRF5) (Ward et al., 2011; Tang et al., 2013). The gene discussed is ADGRG1; the disease is melanoma.