This finding is in agreement with the fact that these diseases as well as RCC are associated with abnormal expression levels of MMPs (Nakamura et al., 2000; Catania et al., 2007; Jiang et al., 2010), including MMP-1 (Nakamura et al., 1993, 2000; Bhuvarahamurthy et al., 2006) which is known to be regulated by Adgrg2 (Richter et al., 2013). Here, ADGRG2 is linked to renal cell carcinoma.