A role of these genes in vascular and/or inflammation-mediated kidney diseases is further substantiated by the associations with diabetes nephritis (ADGRE1, ADGRE5), lupus nephritis (ADGRE1, ADGRE2, ADGRE5), renal vasculitis (ADGRE2, ADGRE5), IgA nephropathy (ADGRE5) and renal hypertension (ADGRE5). The gene discussed is ADGRE5; the disease is lupus nephritis.