Richter and coworkers demonstrated that inhibition of Adgrg2 expression impaired colony formation in vitro (A673, SB-KMS-KS1 and TC-71) and suppressed local tumor growth and metastasis in an immunodeficient mouse xenograft model of human cancer [SB-KMS-KS1/Rag2(−/−)γC(−/−)]. Here, ADGRG2 is linked to cancer.