AHR and intestinal disorder: In DSS-inducible intestinal injury models, AhR-null mice exhibit severe symptoms and mortality (Arsenescu et al., 2011; Benson and Shepherd, 2011), and in another study of intestinal disease models, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced AhR activation decreased lethality and symptom severity (Takamura et al., 2010).