REN and chronic kidney disease: The decrease in proteinuria with THC therapy is noteworthy as increased proteinuria promotes fibrosis and more rapid loss of kidney function in CKD patients46, 47 and associates with higher cardiovascular mortality.48 Anti‐proteinuric interventions are lacking in clinical practice, other than pharmacologic blockade of the renin‐angiotensin‐aldosterone system.49, 50 Concurrent with decreased proteinuria, we noted a trend for improved kidney function as evidenced by lower BUN and plasma creatinine, and higher creatinine clearance in the THC‐treated animals.