CKD is a state of SOD deficiency whereby the latter promotes blood pressure dysregulation and nitric oxide metabolism.39 The observed renoprotective effects in our study are consistent with reports from other rodent models whereby THC enhanced antioxidative activity of superoxide dismutase, catalase and glutathione peroxidase.12, 13, 16 The net effect is decreased production of reactive oxygen species, with subsequent downregulation of the caspase‐3 apoptosis pathway40 and tissue fibrosis. The gene discussed is SOD1; the disease is chronic kidney disease.