SPHK1 and glioblastoma: SphK1 increases the rate of cell proliferation, increases migration and invasion, and inhibits multiple glioma cell lines, in particular LN-229, LN-382, U-87 MG, U-373 MG, U-1242 MG, and primary human non-established GBM GBM6 cells [292, 301, 302].