The effect of orexin-A on tumor volume was dose-dependent as a 30-day treatment with 0.01, 0.1, 1 and 10 μmoles orexin-A/kg decreased the tumor volumes by 34.4, 30.6, 46.7, and 52.8%, respectively (Figure 6B). The gene discussed is HCRT; the disease is neoplasm.