Apoptosis of colon adenocarcinoma cells Caco-2 [41] and hepatocellular carcinoma cells HepG2 [42] was reportedly induced via A2a AR, and activated A2b was found to induce apoptosis in a p73-dependent manor in transfected cancer cells [43]. Here, IGKV2D-29 is linked to colon adenocarcinoma.