Normal or hyperplastic epithelium showed TLR2 and A2a staining in the basal and parabasal cells (Figure 1A, panel “Hyperplasia”), while TLR2- and A2a-positive squamous cells in epithelial dysplasia (ED) and in OSCC were present throughout the lesions. The gene discussed is TLR2; the disease is intraepithelial neoplasia.