AKT1 and systemic lupus erythematosus: Up-regulate genes were mainly enriched in cell cycle, DNA replication, viral carcinogenesis, systemic lupus erythematosus and pyrimidine metabolism pathways; while down-regulate genes were significantly enriched in regulation of lipolysis in adipocytes, PI3K-Akt signaling pathway, PPAR signaling pathway and cytokine-cytokine receptor interaction pathways.